Protein Molecular Weight Markers
ABclonal Technology XPNPEP3 Rabbit pAb
The protein encoded by this gene belongs to the family of X-pro-aminopeptidases that utilize a metal cofactor, and remove the N-terminal amino acid from peptides with a proline residue in the penultimate position. This protein has been shown to localize to the mitochondria of renal cells, and have a role in ciliary function. Mutations in this gene are associated with nephronophthisis-like nephropathy-1. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene, however, expression of some of these isoforms in vivo is not known.
ABclonal Technology ACAA2 Rabbit pAb
The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal.
ABclonal Technology GFPT2 Rabbit pAb
Predicted to enable glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Predicted to be involved in UDP-N-acetylglucosamine metabolic process, fructose 6-phosphate metabolic process, and protein N-linked glycosylation. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cytosol. Implicated in type 2 diabetes mellitus.
ABclonal Technology PDXDC1 Rabbit pAb
Enables cadherin binding activity. Predicted to be involved in carboxylic acid metabolic process. Located in Golgi apparatus.
ABclonal Technology RPS27A Rabbit pAb
This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. Ubiquitin plays a key role in targeting proteins for degradation by the 26S proteasome. When expressed in yeast, the fusion protein is processed into free ubiquitin and ribosomal protein S27a. S27a is part of the 40S ribosomal subunit and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes of this gene are found in the genome. Similar fusion proteins, such as ribosomal protein L40 with ubiquitin and S30 with fubi, are also synthesized. Multiple alternatively spliced transcript variants encoding the same proteins have been identified.
ABclonal Technology SLC26A2 Rabbit pAb
The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein implicated in the pathogenesis of several human chondrodysplasias. It apparently is critical in cartilage for sulfation of proteoglycans and matrix organization.
ABclonal Technology TPRG1L Rabbit pAb
Predicted to enable identical protein binding activity. Predicted to be involved in regulation of glutamatergic synaptic transmission. Located in extracellular exosome.
ABclonal Technology ACTR1B Rabbit pAb
This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 115 in the dynactin complex.
ABclonal Technology CPEB3 Rabbit pAb
Enables mRNA 3-UTR binding activity and translation factor activity, RNA binding. Involved in cellular response to amino acid stimulus, negative regulation of transcription by RNA polymerase II, and positive regulation of mRNA catabolic process. Located in several cellular components, including cytosol, midbody, and nucleoplasm. Part of CCR4-NOT complex.
ABclonal Technology KIF1C Rabbit pAb
The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. Mutations in this gene are a cause of spastic ataxia 2, autosomal recessive.
ABclonal Technology DICER1 Rabbit pAb
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants.
ABclonal Technology GUCY2F Rabbit pAb
The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa.
ABclonal Technology UNC5C Rabbit pAb
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin, they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.
ABclonal Technology CLEC4M Rabbit pAb
This gene encodes a C-type lectin involved in cell adhesion and pathogen recognition. It recognizes a range of pathogens, including tuberculosis mycobacteria, Ebola, HIV-1, influenza A, West Nile virus, and SARS-CoV. The protein has four domains: a C-terminal carbohydrate recognition domain, a flexible neck domain, a transmembrane region, and an N-terminal cytoplasmic domain for internalization. This gene is related to CD209 (DC-SIGN) but differs in viral recognition and expression. It is highly expressed in endothelial cells of the liver, lymph node, and placenta. Polymorphisms in the neck domain are linked to resistance to SARS infection.